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              Home / Services / Research / Research Institutes / Neuroscience Research / Neuroscience Clinical Trials

              Neuroscience Research

              Clinical Trials

              Click here to download a printable copy of this information.

              NEURO-ONCOLOGY

              Primary Site Sponsor/Study ID
              NTC#
              Protocol Description Eligibility
              Recurrent GBM

              (Glioblastoma)
              ECOG-ACRIN

              EAF-151

              NCT03115333
              Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma
              • Histologically proven intracranial glioblastoma or gliosarcoma at initial surgery
              • Karnofsky performance status >= 70
              • Progression of disease assessed by Revised Assessment in Neuro-Oncology (RANO) criteria
              • Patient must not have been treated previously with immunotherapies (vaccines, checkpoint inhibitors, T-cells)
              • Intratumoral hemorrhage as seen MRI may preclude inclusion
              • Progressive enhancement on MRI
              • Patients must be able to tolerate brain MRI scans with dynamic intravenous gadolinium-based contrast agent injections
              • Patient must be scheduled to receive treatment with a standard dose regimen of bevacizumab
              Anaplastic Glioma or Low Grade Glioma National Cancer Institute/Alliance

              N0577

              NCT00887146
              Phase III Intergroup Study of Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma
              • ECOG PS: 0, 1 or 2
              • Newly diagnosed and ≤ 3 months from surgical diagnosis
              • Histological confirmation of anaplastic glioma or low grade glioma
              • Surgery (partial or gross total resection or biopsy) performed ≥ 2 weeks prior to registration with recovering from effects of surgery.
              • Tumor must show 1p/19q codeletion
              Meningioma Grade II National Cancer Institute

              NRG-BN003

              NCT03180268
              Phase III Trial of Observation versus Irradiation for a Gross Totally Resected grade II Meningioma
              • Newly diagnosed unifocal intracranial meningioma, gross totally resection and histologically confirmed Grade II
              • GTR must be confirmed on post-operative imaging following the most recent surgery
              • Post-operative Zubrod performance status 0-1
              Brain Tumor State of Florida

              FCBTR

              NCT00811148
              Florida Center for Brain Tumor Research
              • Adults scheduled to undergo brain surgery to remove tumor tissue
              High grade glioma Tissue collection study Scripps
              1R01CA229737-07

              No NCT #
              Clinical Translation of Precision Medicine Testing Utilizing 3 Dimensional Primary Tumor Cell Culture
              • Patients scheduled to have surgery for removal of brain tumor.
              • Age: 18 years and older.
              Leptomeningeal disease registry Penn State Registry

              No NCT #
              NeMeRe, a Multi-Institutional Retrospective and Prospective Registry of Neoplastic Meningitis in Adults/td>
              • Adults 18 years and older diagnosed and treated with neoplastic meningitis.
              SCLC NRG Oncology

              NRG-CC003

              NCT02635009
              Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer

              Effective 5/28/2020 - enrollment temporarily closed.
              • High-grade neuroendocrine carcinoma or combined SCLC and NSCLC is permitted.
              • Prior to chemotherapy +/- thoracic radiotherapy, patients must be defined as limited-stage or extensive-stage SCLC after clinical staging evaluation.
              • Radiographic partial or complete response to chemotherapy in at least one disease site
              • Patients must have a baseline raw score greater than 2 on the HVLT-R Delayed Recall, as determined by central assessment
              • No Radiographic evidence of CNS metastases
              • Concurrent atezolizumab permitted with PCI
              Brain Metastases Alliance

              A071701

              NCT03994796
              Genetic Testing in Guiding Treatment for Patients with Brain Metastases
              • Histologically confirmed metastatic disease to the brain from any solid tumor.
              • New or progressive brain metastases defined as any one of the following:
                • Untreated measurable lesions in patients who have received surgery and/or SRS to one or more other lesions.
                • Residual or progressive lesions after surgery if asymptomatic.
                • Patients who have had prior WBRT and.or SRS and then whose lesions have progressed by BM-RANO criteria or there are new lesions.
                • Patients who have not previously been treated with cranial radiation must be asymptomatic or neurologically stable from their CNS metastases.
              • Ability to obtain MRIs
              • Tissue available for sequencing (any brain metastasis tissue and extracranial site from any prior resection or biopsy).
              Low to Intermedium Grade Gliomas NRG Oncology

              NRG-BN005

              NCT03180502
              Randomized Phase II Trial of Photon Therapy for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas
              • Grade II and III gliomas IDH mutant.
              • Age 18 and over.
              • Trial is open to both genders.
              • Trial is open to English and French speaking subjects.
              Brain Metastases Alliance

              A071801

              NCT04114981
              Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease
              • Resected brain metastasis must be non-CNS primary site
              • ≤3 unresected brain metastases at the time of screening
              • Unresected lesions must measure <4.0cm in size
              • One brain metastasis must be completely resected ≤30 days prior to registration
              • Resected brain metastasis must measure ≥2 cm
              • Resection cavity must measure <5.0 cm

              NEUROLOGY

              Primary Site Sponsor/Study ID
              NTC#
              Protocol Description Eligibility
              Orthostatic Hypotension in primary autonomic failure Theravance
              0169

              NCT03750552
              A Phase 3, 4-week, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of TD-9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects With Primary Autonomic Failure
              • Meet diagnostic criteria of snOH
              • Score at least 4 on Orthostatic Hypotension Sypmtom Assessment Question 1 at randomization visit
              • PD only: have a diagnosis of PD according to the United Kingdom Parkinson's Disease Society (UKPDS) Brain Bank Criteria (1992)
              • MSA only: have a diagnosis of possible or probable MSA of the Parkinsonian subtype (MSA-P) or cerebellar subtype (MSA-C) according to The Gilman Criteria (2008)
              • PAF only: have impaired autonomic reflexes, as determined by absence of Phase IV BP overshoot after release of the Valsalva strain
              COVID-19 related Acute Respiratory Distress Syndrome Duke University
              NCT 04399889
              Pilot Study of Safety and Efficacy of Cord Tissue Derived Mesenchymal Stromal Cells (hCT-MSC) in COVID-19 related Acute Respiratory Distress Syndrome (ARDS)
              • 18 years and older
              • Tests positive for COVID-19
              • No signs of Multi-organ failure
              Multiple Sclerosis F. Hoffman LaRoche Ltd An Observational Study of Ocrelizumab-Treated Patients with Multiple Sclerosis to Determine the incidence and Mortality Rates of Breast Cancer and All Malignancies (VERISMO Study)
              • 18 years and older
              • Newly treated with ocrelizumab or an approved MS DMT
              Migraines Eli Lilly and Company Preventive Treatment of mIgraine: oUtcoMes for Patients in real-world Healthcare systems (TRIUMPH)
              • 18 years and older
              • Migraine with or without aura
              • Able to reliably report on historical details of headache days
              • Switching to new migraine medication not previously used
              • Access to internet and personal device
              Acute Large Volume Strokes Mercy Health St. Vincent Medical Center

              NCT03805308
              The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke
              • 18-85 years old
              • Presenting to E.D. with symptoms consistent with Acute Ischemic Stroke
              • Imaging evidence of anterior circulation occlusion of ICA or MCA
              • NIHSS >6 at time of randomization, and pre-stroke mRS of 0-1
              • Ability to randomize within 24 hours of stroke onset
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