| Primary Site |
Sponsor/Study ID
NTC#
|
Protocol Description |
Eligibility |
Recurrent GBM
(Glioblastoma)
|
ECOG-ACRIN
EAF-151
NCT03115333
|
Change in Relative Cerebral Blood Volume as a Biomarker for Early Response
to Bevacizumab in Patients with Recurrent Glioblastoma |
- Histologically proven intracranial glioblastoma or gliosarcoma at initial surgery
- Karnofsky performance status >= 70
- Progression of disease assessed by Revised Assessment in Neuro-Oncology
(RANO) criteria
- Patient must not have been treated previously with immunotherapies (vaccines,
checkpoint inhibitors, T-cells)
- Intratumoral hemorrhage as seen MRI may preclude inclusion
- Progressive enhancement on MRI
- Patients must be able to tolerate brain MRI scans with dynamic intravenous
gadolinium-based contrast agent injections
- Patient must be scheduled to receive treatment with a standard dose regimen
of bevacizumab
|
| Anaplastic Glioma or Low Grade Glioma |
National Cancer Institute/Alliance
N0577
NCT00887146
|
Phase III Intergroup Study of Temozolomide Alone versus Radiotherapy with
Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant
PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma
or Low Grade Glioma |
- ECOG PS: 0, 1 or 2
- Newly diagnosed and ≤ 3 months from surgical diagnosis
- Histological confirmation of anaplastic glioma or low grade glioma
- Surgery (partial or gross total resection or biopsy) performed ≥ 2 weeks
prior to registration with recovering from effects of surgery.
- Tumor must show 1p/19q codeletion
|
| Meningioma Grade II |
National Cancer Institute
NRG-BN003
NCT 03180268
|
Phase III Trial of Observation versus Irradiation for a Gross Totally Resected
grade II Meningioma |
- Newly diagnosed unifocal intracranial meningioma, gross totally resection
and histologically confirmed Grade II
- GTR must be confirmed on post-operative imaging following the most recent surgery
- Post-operative Zubrod performance status 0-1
|
| Adult Glioma and Meningioma |
National Cancer Institute / Moffitt Cancer
15004
No NCT #
|
Southeastern Study of Cancer and the Environment |
- Primary diagnosis of glioma or meningioma any grade
- GBM dx within 1 year, Anaplastic astrocytoma grade III dx within 5 years,
grate 2 or less gliomas no restrictions.
- At least 18 years of age
- Residents of the US
|
| Brain Tumor |
State of Florida
FCBTR
NCT00811148
|
Florida Center for Brain Tumor Research |
- Adults scheduled to undergo brain surgery to remove tumor tissue
|
| High grade glioma Tissue collection study |
Scripps
1R01CA229737-07
No NCT #
|
Clinical Translation of Precision Medicine Testing Utilizing 3 Dimensional
Primary Tumor Cell Culture |
- Patients scheduled to have surgery for removal of brain tumor.
- Age: 18 years and older.
|
| Leptomeningeal disease registry |
Penn State Registry
No NCT #
|
NeMeRe, a Multi-Institutional Retrospective and Prospective Registry of
Neoplastic Meningitis in Adults/td>
|
- Adults 18 years and older diagnosed and treated with neoplastic meningitis.
|
| SCLC |
NRG Oncology
NRG-CC003
NCT02635009
|
Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With
or Without Hippocampal Avoidance for Small Cell Lung Cancer
|
- High-grade neuroendocrine carcinoma or combined SCLC and NSCLC is permitted.
- Prior to chemotherapy +/- thoracic radiotherapy, patients must be defined
as limited-stage or extensive-stage SCLC after clinical staging evaluation.
- Radiographic partial or complete response to chemotherapy in at least one
disease site
- Patients must have a baseline raw score greater than 2 on the HVLT-R Delayed
Recall, as determined by central assessment
- No Radiographic evidence of CNS metastases
- Concurrent atezolizumab permitted with PCI
|